HeatFlow Technologies
Technology
HeatFlow Technologies'™ Inc. novel and proprietary HeatFlow™ Polymerase Chain Reaction (HF-PCR™) encompasses the instrumentation, methods, reagents, kits, and software needed to conduct HF-PCR™. PCR is a technique in molecular biology used to amplify life's building block nucleic acids (DNA or RNA). PCR and related nucleic acid amplification techniques (NAAT) are frequently used in molecular biology research and clinical medical laboratories to quantify or identify the presence of specific nucleic acid sequences.
In the clinical laboratory, HF-PCR™ can be used to monitor infectious diseases (e.g., HIV-infection and chronic hepatitis), diagnose infectious diseases (e.g., influenza, strep throat, MRSA, HPV), diagnose genetic diseases (e.g., cystic fibrosis, hereditary hemochromatosis, and hereditary hypercoagulability), and characterize cancers (e.g., leukemia, breast cancer, and cervical dysplasia). In research laboratories, HF-PCR™ can replace almost any established PCR-NAAT in vitro diagnostic (IVD) technique.
Unlike older methods of realtime quantitative PCR (qPCR), HF-PCR™ simplifies the PCR reaction to its fundamental constituents. HF-PCR™ detects successful PCR reactions by directly measuring the heat flow into the PCR reaction solution. Other realtime PCR systems and methods require sensitive optical pathways, light sources, fluorescent detectors, and fluorescent reagents. HF-PCR™ is free of these complexities resulting in lower cost and more rugged systems.
HeatFlow Technologies' ™ revolutionary simplification of the PCR reaction allows the expansion of PCR IVD and clinical diagnostics. Current older technology qPCR is limited to high and moderate complexity clinical laboratories or highly-skilled molecular biology research laboratories. There are no FDA-approved point-of-care (POC) NAAT-PCR diagnostic tests in the United States. HeatFlow Technologies™ and its partners are moving forward with the further development of POC clinical diagnostics and low-cost realtime qPCR systems and methods.
